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  • PMLSC Assay Protocol Review Document for MKP-1 HTS
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    bullet point  Necroptosis PMLSC APAC Document
     
     
    Necrosis is a caspase-independent cell death marked by a rapid loss of plasma membrane integrity, organelle swelling and mitochondrial dysfunction, and lacking typical features of apoptosis such as internucleosomal DNA cleavage and nuclear condensation. Necrosis has been reported to occur under a variety of pathological conditions, including both acute and chronic neurodegenerative disorders (8, 9) and may also occur during normal development of the nervous system (10, 11). Recent studies have found the classical morphological features of necrosis in the developing nervous system of apaf-1-/-, caspase-3-/- and caspase-9-/- mice which lack a part of the core apoptotic machinery (12). While necrosis has traditionally been viewed as an uncontrolled pathologic cell death, these studies support the concept that cells possess a caspase-independent but regulated cell death mechanism distinct from that of apoptosis, and the activation of this alternative mechanism leads to cell death with features resembling necrosis.
     
    Documents
  • Necroptosis PMLSC APAC Document
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