|
|
 |
| |
 Related References Published by Members of the PMLSC |
| |
| |
Arnold, D.M., et al., Synthesis and biological activity of a focused library of mitogen-activated protein kinase phosphatase inhibitors. Chem Biol Drug Des, 2007. 69: p. 23-30.
Johnston, An interview with Paul A. Johnston, Ph.D., by Vicki Glaser. Assay Drug Dev Technol., 2007. 5(3): p. 289-97.
Johnston, P.A., et al., Development and implementation of a 384-well homogeneous fluorescence intensity high-throughput screening assay to identify mitogen-activated protein kinase phosphatase-1 dual-specificity protein phosphatase inhibitors. Assay Drug Dev Technol, 2007. 5: p. 319-32.
Johnston, P.A., et al., High throughput screening (HTS) identifies novel and specific uncompetitive inhibitors of the two-componenet NS2B-NS3 proteinase of West Nile virus. Assay Drug Dev Technol. 5: p 737-750
Lazo, J.S., Roadmap or roadkill: a pharmacologist's analysis of the NIH Molecular Libraries Initiative. Mol Interv, 2006. 6: p. 240-3.
Lazo, J.S., L.S. Brady, and R. Dingledine, Building a pharmacological lexicon: small molecule discovery in academia. Mol Pharmacol, 2007. 72: p. 1-7.
Sharlow, E.R., et al., Development and Implementation of a Miniaturized High Throughput Timed-Resolved – Fluorescence Energy Transfer Assay to Identify Small Molecule Inhibitors of Polo-like Kinase I. Assay Drug Dev Technologies, 2007. 5: p. 723-735.
Tierno, M.B., et al., Development and optimization of high-throughput in vitro protein phosphatase screening assays. Nat Protoc, 2007. 2: p. 1134-44.
Vogt, A. and J.S. Lazo, Discovery of protein kinase phosphatase inhibitors. Methods Mol Biol, 2007. 356: p. 389-400.
Vogt, A. and J.S. Lazo, Implementation of high-content assay for inhibitors of mitogen-activated protein kinase phosphatases. Methods, 2007. 42: p. 268-77.
Guo, J., Parise, R., Joseph, E., Egorin, M. Lazo, J.S., Prochownik, E., and Eiseman, J. Efficacy, pharmacokinetics, tissue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice. Cancer Chemother Pharmacol. In Press
Sharlow, E.R., Leimgruber, S., Yellow-Duke, A., Barrett, R., Wang, Q.J., and Lazo, J.S. Development, validation and implementation of immobilized metal affinity for phosphochemicals (IMAP)-based high-throughput screening assays for low-molecular-weight compound libraries. Nature Protocols. In Press
Lazo, J.S. Speaking of Pharmacology, Rear-view mirrors and crystal balls: A brief reflection on drug discovery. Mol Interv. 8:60-63, 2008.
Queiroz de Oliveira, P.E., Tomko, R.J. Jr, and Lazo, J.S. Is a step backwards in s-phase-targeted chemotherapy a step forward? Mol Interv. 8:137-40, 2008. PMID: 18693192
Hermone, A. R., Burnett, J. C., Nuss, J. E., Tressler, L. E., Nguyen, T. L., Solaja, B. A., Vennerstrom, J. L., Schmidt, J. J., Wipf, P., Bavari, S., and Gussio, R. Three-Dimensional Database Mining Identifies a Unique Chemotype that Unites Structurally Diverse Botulinum Neurotoxin Serotype A Inhibitors in a Three-Zone Pharmacophore. Chem Med Chem. In Press, 2008.
Timmons, C.; Wipf, P. J. DFT Calculation of 13C NMR Shifts of Phenanthrenoid Alkaloids: Reinvestigation of the Structure of Samoquasine A. Org Chem. In Press, 2008.
Rabu, C., Wipf, P. and Brodsky, J. L. High, S. J. A Precursor Specific Role for Hsp40/Hsc70 during Tail-Anchored Protein Integration at the Endoplasmatic Reticulum. Biol Chem. In Press, 2008.
Gu, L.; Wang, B., Kulkarni, A., Geders, T. W., Grindberg, R. V., Gerwick, L., Hakansson, K., Wipf, P., Smith, J. L., Gerwick, W. H., and Sherman, D. H. Nature Metamorphic Enzyme Assembly in Polyketide Diversification. Chem Biol. Submitted, 2008,
Pierce, J. G., Kasi, D., Fushimi, M., Cuzzupe, A., and Wipf, P. Synthesis of Hydroxylated Bicyclic Amino Acids from L-Tyrosine: Octahydro-1H-indole Carboxylates. Org Chem. In Press, 2008.
Bakan, A., Lazo, J. S., Wipf, P., Brummond, K. M., and Bahar, I. Toward a Molecular Understanding of the Interaction of Dual Specificity Phosphatases with Substrates: Insights from Structure-Based Modeling and High Throughput Screening. Curr. Med. Chem. In Press, 2008.
Johnston, P. A., Soares, K. M., Shinde, S. N., Foster, C. A., Shun, T. Y., Takyi, H. K., Wipf, P., and Lazo, J. S. Development of a 384-well Colorimetric Assay to Quantify Hydrogen Peroxide Generated by the Redox Cycling of Compounds in the Presence of Reducing Agents. Assay Drug Dev Technol. In Press, 2008.
Faraji, A. H.; Wipf, P. Nanoparticles in Cellular Drug Delivery. Comb Chem High Throughput Screen. In Press, 2008.
Keinan, S., Paquette, W. D., Skoko, J. J., Beratan, D. N., Yang, W., Shinde, S., Johnston, P. A., Lazo, J. S., and Wipf, P. Computational Design, Synthesis and Biological Evaluation of para-Quinone-Based Inhibitors for Redox Regulation of the Dual-Specificity Phosphatase Cdc25B. Org Biomol Chem. 6:3256-3263, 2008.
Lazo, J. S.; Wipf, P. Is Cdc25 a Druggable Target? Anti-Cancer Agents Med Chem. In Press, 2008.
Wipf, P. Sixteen Semesters of Chemistry at the University of Zürich: A Retrospective on a Formative Time. Chimia 62:150-151, 2008.
Walczak, M. A. A., and Wipf, P. J. Rhodium(I)-Catalyzed Cycloisomerizations of Bicyclobutanes. Am Chem Soc. 130:6924-6925, 2008.
Ihle, N. T., Lemos, R., Wipf, P., Yacoub, A., Mitchell, C., Siwak, D., Mills, G. B., Dent, P., Kirkpatrick, D. L., and Powis, G. Identification of Oncogenic Ras as a Marker for Intrinsic in vivo Resistance to Single Agent Activity of the Specific PI-3-Kinase Inhibitor, PX-866. xxx. Submitted, 2008.
Braunstein, M. J., Scott, C. M., Behrman, S., Walter, P., Wipf, P., Smith, E. L. P., Brodsky, J. L., Batuman, O. Inhibitors of the Hsp70 Molecular Chaperone and the Proteasome Show Synergistic Antimyeloma Effects. Cancer Res. Submitted, 2008.
A Vogt, A., McDonald, P. R., Tamewitz, A., Sikorski, R. P., Wipf, P., Skoko, J. J., and Lazo, J. S. Cell-Active Inhibitor of Mitogen-Activated Protein Kinase Phosphatases Restores Paclitaxel-Induced Apoptosis in Dexamethasone-Protected Cancer Cells. Mol Cancer Ther. 7: 330-340, 2008.
Jiang, J., Belikova, N., Hoye, A. T., Zhao, Q., Epperly, M. W., Greenberger, J. S., Wipf, P., and Kagan, V. E. A Mitochondria-Targeted Nitroxide/Hemigramicidin S Conjugate Protects Mouse Embryonic Cells Against Gamma Irradiation. Int J Radiat Oncol Biol Phys. 70: 816-825, 2008.
Feng, L., Du, D., Fuller, A. A., Davoren, J. E., Wipf, P., Kelly, J. W., and Gruebele, M. An Experimental Survey of the Transition between Two-State and Downhill Protein Folding Scenarios. Proc Natl Acad Sci USA. 105:2369-2374, 2008.
Balachandran, R., Hopkins, T. D., Thomas, C. A., Wipf, P., and Day, B. W. Tubulin-Perturbing Naphthoquinone Spiroketals. Chem Biol Drug Desig. 71:117-124, 2008.
Zuber, G., Wipf, P., and Beratan, D. N. Exploring the Optical Activity Tensor by Anisotropic Rayleigh Optical Activity Scattering. ChemPhysChem. 9: 265-271, 2008.
Wright, C. M., Chovatiya, R. J., Jameson, N. E., Turner, D. M., Zhu, G., Werner, S., Huryn, D. M., Pipas, J. M., DayB. W., Wipf, P., and Brodsky, J. L. Pyrimidinone-Peptoid Hybrid Molecules with Distinct Effects on Molecular Chaperone Function and Breast Cancer Cell Proliferation. Bioorg Med Chem. 16:3291-3301, 2008.
Hoye, A. T., Davoren, J., Wipf, P., Fink, M. P., and Kagan, V. E. Targeting Mitochondria. Acc Chem Res. 41:87–97, 2008.
Ihle, N. T., Lemos, R., Schwartz, D., Oh, J., Halter, R. J., Wipf, P., Kirkpatrick, D. L., and Powis, G. The PPARg Agonist Pioglitazone Prevents the Increase in Blood Glucose Caused by Phosphoinositide-3-kinase Pathway Inhibition without Blocking Antitumor Activity. Clin Cancer Res. Submitted, 2008.
Wipf, P. and Jayasuriya, N. Chiral Ligand Optimization in the Asymmetric Zirconium-Zinc Transmetalation Aldehyde Addition Reaction. Chirality. 20:425-430, 2008.
Shrivastava IH, Jiang J, Amara SG and Bahar I. Time-resolved mechanism of extracellular gate opening and substrate binding in glutamate transporter. J Biol Chem, 2008. PMID: 18678877.
Engen JR, Wales TE, Hochrein JM, Meyn MA III, Ozkan SB, Bahar I and Smithgall TE. Structure and dynamic regulation of Src-family kinases. Cell Mol Life Sci, 2008. PMID: 18563293.
Bagci EZ, Vodovotz Y, Billiar TR, Ermentrout B and Bahar I. Computational Insights on the Competing Effects of Nitric Oxide in Regulating Apoptosis. PLoS ONE 3, e2249, 2008.
Isin B, Schulten K, Tajkhorshid E, Bahar I. Mechanism of Signal Propagation upon Retinal Isomerization: Insights from Molecular Dynamics Simulations of Rhodopsin Restrained by Normal Modes. Biophysical J. 95: 789-803, 2008. PMID: 18390613
Liu Y, Eyal E, Bahar I. Analysis of correlated mutations in HIV-1 protease using spectral clustering. Bioinformatics. 24:1243-50, 2008. PMID: 18375964
C. Chennubhotla, Z. Yang and Bahar I. Coupling between global dynamics and signal transduction pathways: a mechanism of allostery for chaperonin GroEL. Mol. BioSyst. 4:287-292, 2008.
Eyal E, Bahar I. Toward a molecular understanding of the anisotropic response of proteins to external forces: insights from elastic network models. Biophys J. 94:3424-35, 2008.
Johnston PA, Soares KM, Shinde SN, Foster CA, Shun TY, Takyi HK, Wipf P, and Lazo JS. Development of a 384-well Colorimetric Assay to Quantify Hydrogen Peroxide Generated by the Redox Cycling of Compounds in the Presence of Reducing Agents. Assay and Drug Development Technologies. In Press, 2008.
Keinan S, Paquette WD, Skoko JJ, Beratan DN, Yang W, Shinde S, Johnston PA, Lazo JS, and Wipf P. Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B. Org Biomol Chem. In Press, 2008.
Raccor,B.S., Vogt,A., Sikorski,R.P., Madiraju,C., Balachandran,R., Montgomery,K., Shin,Y., Fukui,Y., Jung,W.H., Curran,D.P., and Day,B.W. (2008). Cell-based and biochemical structure-activity analyses of analogs of the microtubule stabilizer dictyostatin. Mol. Pharmacol. 73, 718-726.
Vogt,A., McDonald,P.R., Tamewitz,A., Sikorski,R.P., Wipf,P., Skoko,J.J., III, and Lazo,J.S. (2008). A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells. Mol. Cancer Ther. 7, 330-340.
Zou,H., Thomas,S.M., Yan,Z.W., Grandis,J.R., Vogt,A., and Li,L.Y. (2008). Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells. FASEB J [epub ahead of print]
|
| |
| |
to top |
|
|
| |
| HCS Related References |
| |
| |
Gough, A.H. and P.A. Johnston, Requirements, features and performance of high content screening platforms, in high content screening: a powerful approach to systems cell biology and drug discovery. Methods in Molecular Biology, 2006. 356: p. 41-61.
Williams, R.G., et al., Generation and characterization of a stable MK2-EGFP cell line and subsequent development of a high-content imaging assay on the Cellomics ArrayScan platform to screen for p38 mitogen-activated protein kinase inhibitors. Methods Enzymol, 2006. 414: p. 364-89.
Trask, O.J., Jr., et al., Assay development and case history of a 32K-biased library high-content MK2-EGFP translocation screen to identify p38 mitogen-activated protein kinase inhibitors on the ArrayScan 3.1 imaging platform. Methods Enzymol, 2006. 414: p. 419-39.
Nickischer, D., et al., Development and implementation of three mitogen-activated protein kinase (MAPK) signaling pathway imaging assays to provide MAPK module selectivity profiling for kinase inhibitors: MK2-EGFP translocation, c-Jun, and ERK activation. Methods Enzymol, 2006. 414: p. 389-418.
Madiraju, C., et al., Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin. Biochemistry, 2005. 44: p. 15053-63.
Vogt, A., et al., Cell-active dual specificity phosphatase inhibitors identified by high-content screening. Chem Biol, 2003. 10: p. 733-42.
Vogt, A., E.N. Kalb, and J.S. Lazo, A scalable high-content cytotoxicity assay insensitive to changes in mitochondrial metabolic activity. Oncol Res, 2004. 14: p. 305-14.
Vogt, A. and J.S. Lazo, Chemical complementation: a definitive phenotypic strategy for identifying small molecule inhibitors of elusive cellular targets. Pharmacol Ther, 2005. 107: p. 212-21.
Vogt, A. and J.S. Lazo, Discovery of protein kinase phosphatase inhibitors. Methods Mol Biol, 2007. 356: p. 389-400.
Vogt, A. and J.S. Lazo, Implementation of high-content assay for inhibitors of mitogen-activated protein kinase phosphatases. Methods, 2007. 42: p. 268-77.
Vogt, A., et al., Spatial analysis of key signaling proteins by high-content solid-phase cytometry in Hep3B cells treated with an inhibitor of Cdc25 dual-specificity phosphatases. J Biol Chem, 2001. 276: p. 20544-50.
Vogt, A., et al., The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1. J Biol Chem, 2005. 280: p. 19078-86.
Vogt, A., et al., The antisignaling agent SC-alpha alpha delta 9, 4-(benzyl-(2-[(2,5-diphenyloxazole-4-carbonyl)amino]ethyl)carbamoyl)- 2-decanoylaminobutyric acid, is a structurally unique phospholipid analogue with phospholipase C inhibitory activity. Mol Cancer Ther, 2002. 1: p. 885-92.
P. A. Johnston. (2007) “Automated High Content Screening Microscopy” Chapter 2, p25-42, in High Content Screening: Science, Technology and Applications. John Wiley & Sons, Inc; Edited by: Stephen A. Haney.
|
| |
| |
to top |
|
|
| |
| HTS Related References |
| |
| |
Carpenter, J; C. Laethem, F. R. Hubbard, T. K. Eckols, M. Baez, D. McClure, D. L. G. Nelson, and P. A. Johnston. (2002). Configuring Radioligand receptor Binding Assays for HTS using Scintillation Proximity Assay Technology. High Throughput Screening: Methods and Protocols, in Methods in Molecular Biology, 190: 31-49. The Humana Press, Inc. Edited by W. P. Janzen.
Johnston, P. A. and P. A. Johnston (2002). Cellular Platforms for HTS: three case studies. Drug Discovery Today 7: 353-363.
Pratt S, Shepard RL, Kandasamy RA, Johnston PA, Perry W 3rd, and Dantzig AH. (2005). The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites. Mol. Cancer Ther. 4:855-63.
Razonable RR, Henault M, Lee LN, Laethem C, Johnston PA, Watson HL, Paya CV. (2005) Secretion of proinflammatory cytokines and chemokines during amphotericin B exposure is mediated by coactivation of toll-like receptors 1 and 2 Antimicrob Agents Chemother. 49(4):1617-21.
|
| |
| |
to top |
|
|
| |
| |
|
