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    Instrumentation/Platforms
     
    bullet point  Compound Storage and Retrieval
     
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    PMLSC has a Matrical MatriMinistore Modular Compound Store platform with 3 VLM modules and capacity for 12,900 384-well plates, ~ 4.95 M compounds, which is integrated with the LIMS to manage the compound storage and retrieval. The following lists this platform's features:

  • Automated compound storage and retrieval system

  • Expanded system starting at 1500 compound plates

  • Fast retrieval in excess of 10,000 samples per day

  • Storage conditions include Room Temperature from 40C to -200C

  • Centralized storage and retrieval information management

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    bullet point  Liquid Handling
     
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    Automated Liquid Handlers for Compound Handling and Assay Implementation:
  • (2) Biomek 2000 automated liquid handling systems
  • (1) Velocity 11 V-prep liquid handling system with 96-well and 384-well transfer heads
  • (1) Velocity 11 Bravo liquid handling system with 384-well transfer head
  • (1) Perkin Elmer Multiprobe 8-Tip with a 16 plate deck configuration liquid handling system outfitted with (1) dual 50-plate magazine plate stacker
  • (1) Perkin Elmer Evolution EP3 liquid handling system equipped with both 96-well and 384-well transfer heads and (2) dual 50-plate magazine plate stackers
  • (1) Perkin Elmer Janus Multiprobe 8-Tip with a 24 plate deck configuration liquid handling system outfitted with (1) dual 50-plate magazine plate stacker
  • (1) Perkin Elmer Janus MDT liquid handling system equipped with both 96-well and 384-well transfer heads integrated with an Abgene automated plate sealer and outfitted with (2) dual 50-plate magazine plate stackers,
  • (1) Titertek Zoom dispenser outfitted with (1) dual 50-plate magazine plate stacker
  • (1) Titertek MAP-C2 plate washer and reagent dispenser outfitted with (1) dual 50-plate magazine plate stacker
  • (1) Molecular Devices AquaMax DW4 96- and 384-well plate washer and reagent dispenser integrated with the Synchromax ET plate handler
  • (1) Perkin Elmer FlexDrop IV reagent dispenser with 50-plate stacker capacity
  • (1) Perkin Elmer Unifilter-96 Harvester, (2) Biotek Elx405 Plate Washers with (2) dual 25-plate magazine plate stackers
  • (1) Biotek Microflo Bulk Reagent Dispenser with (1) dual 50-plate magazine plate stacker
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    bullet point  Detection Instruments
     
    Click to view large arrayscan copy.JPG Click to view large M5 copy.JPG Click to view large imagexpress_ultra_270.jpg
     
       
     
    HTS/HCS Detection Instruments:
  • (1) Cellomics ArrayScan II upgraded to a version IV integrated with a Zymarker Twister I plate handler
  • (1) Cellomics ArrayScan VTi integrated with a Caliper Twister II plate handler
  • (3)Molecular Devices SpectraMax M5 plate readers integrated with dual 40-plate magazine StackMax plate stackers
  • (1) Molecular Devices Flexstation III kinetic microtiter plate reader
  • (1) Perkin Elmer EnVision multilabel plate reader with AlphaScreen capability with dual 50-plate magazine plate stackers
  • (1) Perkin Elmer 96-well 2-detector Topcount scintillation and luminescence counter
  • (2) Molecular Devices ImageXpress Ultra Confocal Imaging Systems integrated with (1) CRS Catalyst Express plate-loading robot fitted with 45-plate capacity
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    bullet point  Specialized HTS/HCS Equipment
     
     
    Compound storage and retrieval system: (1) Matrical MatriMinistore™ with 3 VLM modules and capacity for 12,900 384-well plates, ~ 4.95 M compounds.

    Automated Liquid Handlers for Compound Handling and Assay Implementation: (2) Biomek 2000 automated liquid handling systems, (1) Velocity 11 V-prep liquid handling system with 96-well and 384-well transfer heads, (1) Perkin Elmer Multiprobe 8-Tip with a 16 plate deck configuration liquid handling system outfitted with (1) dual 50-plate magazine plate stacker (1) Perkin Elmer Evolution EP3 liquid handling system equipped with both 96-well and 384-well transfer heads and (2) dual 50-plate magazine plate stackers, (1) Perkin Elmer Janus Multiprobe 8-Tip with a 24 plate deck configuration liquid handling system outfitted with (1) dual 50-plate magazine plate stacker, (1) Perkin Elmer Janus Evolution EP3 liquid handling system equipped with both 96-well and 384-well transfer heads integrated with an Abgene automated plate sealer and outfitted with (2) dual 50-plate magazine plate stackers, (1) Titertek Zoom dispenser outfitted with (1) dual 50-plate magazine plate stacker, (1) Titertek MAP-C2 plate washer and reagent dispenser outfitted with (1) dual 50-plate magazine plate stacker, (1) Molecular Devices AquaMax DW4 96- and 384-well plate washer and reagent dispenser integrated with the Synchromax ET plate handler, (1) Perkin Elmer FlexDrop IV reagent dispenser with 50-plate stacker capacity, (1) Perkin Elmer Unifilter-96 Harvester.

    HTS/HCS Detection Instruments: (1) Cellomics ArrayScan II upgraded to a version IV integrated with a Zymarker Twister I plate handler, (1) Cellomics ArrayScan VTi integrated with a Caliper Twister II plate handler, (2) Molecular Devices SpectraMax M5 plate readers integrated with dual 40-plate magazine StackMax plate stackers, (1) Molecular Devices Flexstation III kinetic microtiter plate reader, (1) Perkin Elmer EnVision multilabel plate reader with AlphaScreen capability with dual 50-plate magazine plate stackers, (1) Perkin Elmer 96-well 2-detector Topcount scintillation and luminescence counter.

    Robotic Plate Handlers: (1) Zymarker Twister I plate handler, (1) Molecular Devices Synchromax ET plate handler, (1) Caliper Twister II plate handler, all operated with iLink control software.

     
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