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| Instrumentation/Platforms |
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 Compound Storage and Retrieval |
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PMLSC has a Matrical MatriMinistore Modular Compound Store platform with 3 VLM modules and capacity for 12,900 384-well plates, ~ 4.95 M compounds, which is integrated with the LIMS to manage the compound storage and retrieval. The following lists this platform's features:
Automated compound storage and retrieval system
Expanded system starting at 1500 compound plates
Fast retrieval in excess of 10,000 samples per day
Storage conditions include Room Temperature from 40C to -200C
Centralized storage and retrieval information management
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| Liquid Handling |
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Automated Liquid Handlers for Compound Handling and Assay Implementation:
(2) Biomek 2000 automated liquid handling systems
(1) Velocity 11 V-prep liquid handling system with 96-well and 384-well transfer heads
(1) Velocity 11 Bravo liquid handling system with 384-well transfer head
(1) Perkin Elmer Multiprobe 8-Tip with a 16 plate deck configuration liquid handling system outfitted with (1) dual 50-plate magazine plate stacker
(1) Perkin Elmer Evolution EP3 liquid handling system equipped with both 96-well and 384-well transfer heads and (2) dual 50-plate magazine plate stackers
(1) Perkin Elmer Janus Multiprobe 8-Tip with a 24 plate deck configuration liquid handling system outfitted with (1) dual 50-plate magazine plate stacker
(1) Perkin Elmer Janus MDT liquid handling system equipped with both 96-well and 384-well transfer heads integrated with an Abgene automated plate sealer and outfitted with (2) dual 50-plate magazine plate stackers,
(1) Titertek Zoom dispenser outfitted with (1) dual 50-plate magazine plate stacker
(1) Titertek MAP-C2 plate washer and reagent dispenser outfitted with (1) dual 50-plate magazine plate stacker
(1) Molecular Devices AquaMax DW4 96- and 384-well plate washer and reagent dispenser integrated with the Synchromax ET plate handler
(1) Perkin Elmer FlexDrop IV reagent dispenser with 50-plate stacker capacity
(1) Perkin Elmer Unifilter-96 Harvester, (2) Biotek Elx405 Plate Washers with (2) dual 25-plate magazine plate stackers (1) Biotek Microflo Bulk Reagent Dispenser with (1) dual 50-plate magazine plate stacker |
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| Detection Instruments |
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HTS/HCS Detection Instruments:
(1) Cellomics ArrayScan II upgraded to a version IV integrated with a Zymarker Twister I plate handler
(1) Cellomics ArrayScan VTi integrated with a Caliper Twister II plate handler
(3)Molecular Devices SpectraMax M5 plate readers integrated with dual 40-plate magazine StackMax plate stackers
(1) Molecular Devices Flexstation III kinetic microtiter plate reader
(1) Perkin Elmer EnVision multilabel plate reader with AlphaScreen capability with dual 50-plate magazine plate stackers
(1) Perkin Elmer 96-well 2-detector Topcount scintillation and luminescence counter
(2) Molecular Devices ImageXpress Ultra Confocal Imaging Systems integrated with (1) CRS Catalyst Express plate-loading robot fitted with 45-plate capacity
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| Specialized HTS/HCS Equipment |
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Compound storage and retrieval system: (1) Matrical MatriMinistore™ with 3 VLM modules and capacity for 12,900 384-well plates, ~ 4.95 M compounds.
Automated Liquid Handlers for Compound Handling and Assay Implementation: (2) Biomek 2000 automated liquid handling systems, (1) Velocity 11 V-prep liquid handling system with 96-well and 384-well transfer heads, (1) Perkin Elmer Multiprobe 8-Tip with a 16 plate deck configuration liquid handling system outfitted with (1) dual 50-plate magazine plate stacker (1) Perkin Elmer Evolution EP3 liquid handling system equipped with both 96-well and 384-well transfer heads and (2) dual 50-plate magazine plate stackers, (1) Perkin Elmer Janus Multiprobe 8-Tip with a 24 plate deck configuration liquid handling system outfitted with (1) dual 50-plate magazine plate stacker, (1) Perkin Elmer Janus Evolution EP3 liquid handling system equipped with both 96-well and 384-well transfer heads integrated with an Abgene automated plate sealer and outfitted with (2) dual 50-plate magazine plate stackers, (1) Titertek Zoom dispenser outfitted with (1) dual 50-plate magazine plate stacker, (1) Titertek MAP-C2 plate washer and reagent dispenser outfitted with (1) dual 50-plate magazine plate stacker, (1) Molecular Devices AquaMax DW4 96- and 384-well plate washer and reagent dispenser integrated with the Synchromax ET plate handler, (1) Perkin Elmer FlexDrop IV reagent dispenser with 50-plate stacker capacity, (1) Perkin Elmer Unifilter-96 Harvester.
HTS/HCS Detection Instruments: (1) Cellomics ArrayScan II upgraded to a version IV integrated with a Zymarker Twister I plate handler, (1) Cellomics ArrayScan VTi integrated with a Caliper Twister II plate handler, (2) Molecular Devices SpectraMax M5 plate readers integrated with dual 40-plate magazine StackMax plate stackers, (1) Molecular Devices Flexstation III kinetic microtiter plate reader, (1) Perkin Elmer EnVision multilabel plate reader with AlphaScreen capability with dual 50-plate magazine plate stackers, (1) Perkin Elmer 96-well 2-detector Topcount scintillation and luminescence counter.
Robotic Plate Handlers: (1) Zymarker Twister I plate handler, (1) Molecular Devices Synchromax ET plate handler, (1) Caliper Twister II plate handler, all operated with iLink control software.
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