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  • Inhibitors of the NS3 Proteinase of West Nile Virus
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    PMLSC Probe Reports
     
    bullet point  Inhibitors of the NS3 Proteinase of West Nile Virus
     
     
    Specific Aim: Identify drug-like small molecule inhibitors of the NS3 West Nile virus protease by high throughput screening of chemical libraries.
    Future plans include optimization the structure of the novel, low-molecular weight, synthetic inhibitors of the West Nile and Dengue virus NS3 proteinase and to validate the selectivity and potency of the selected compound leads in additional in vitro tests and assays. In addition, we will determine, at the atomic resolution level, the structure of the NS3 protease bound to lead antagonists. Recent exciting discoveries directly related to this particular project [1] and vast amounts of structure-activity data that should flow from this project should facilitate creation of therapeutically important, anti-viral, drugs.
     
    Documents
  • PMLSC WNV NS2B-NS3 Probe Report
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